Cocoș, R. and Popescu, B.O. (2024) Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens. Hum Genomics. 18(1):141. Neurodegenerative diseases present complex genetic architectures, reflecting a continuum from monogenic to oligogenic and polygenic models. Recent advances in multi-omics data, c...
Stilpeanu, R.I., Secara, B.S., Cretu-Stancu, M.*, Bucur, O.* (2024) Oncolytic Viruses as Reliable Adjuvants in CAR-T Cell Therapy for Solid Tumors. Int J Mol Sci. 25(20):11127. Although impactful scientific advancements have recently been made in cancer therapy, there remains an opportunity for future improvements. Immunotherapy is perhaps one of t...
Mircea, A.A., Pistritu, D.V., Fortner, A., Tanca, A., Liehn, E.A. *, Bucur, O.* (2024) Space Travel: The Radiation and Microgravity Effects on the Cardiovascular System. Int J Mol Sci. 25(21):11812. Space flight modulates the functions of the cardiovascular system. The exposure to space conditions can alter the cerebral blood flow, as well as the v...
Chera, A., Stancu-Cretu, M.*, Zabet, N.R. *, Bucur, O.* (2024) Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology. Epigenetics Chromatin. 17(1):39. DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome ina...
Fortner, A. and Bucur, O. (2024) Multiplexed spatial transcriptomics methods and the application of expansion microscopy. Front. Cell Dev. Biol. 12:1378875. While spatial transcriptomics has undeniably revolutionized our ability to study cellular organization, it has driven the development of a great number of innovative transcriptomics methods, wh...
Georgescu, G.C., Cretu-Stancu, M. & Bucur, O. (2024) Metformin drugs under simulated gastric conditions can generate high nitrite-dependent levels of N-nitrosodimethylamine. Sci Rep 14, 13910. N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA), group 2A carcinogens, were detected in finished drug products, including metformin,...
