Cocoș, R. and Popescu, B.O. (2024) Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens. Hum Genomics. 18(1):141. Neurodegenerative diseases present complex genetic architectures, reflecting a continuum from monogenic to oligogenic and polygenic models. Recent advances in multi-omics data, coupled with systems genetics, have significantly refined our understanding of how these data

Stilpeanu, R.I., Secara, B.S., Cretu-Stancu, M.*, Bucur, O.* (2024) Oncolytic Viruses as Reliable Adjuvants in CAR-T Cell Therapy for Solid Tumors. Int J Mol Sci. 25(20):11127. Although impactful scientific advancements have recently been made in cancer therapy, there remains an opportunity for future improvements. Immunotherapy is perhaps one of the most cutting-edge categories of therapies

Mircea, A.A., Pistritu, D.V., Fortner, A., Tanca, A., Liehn, E.A. *, Bucur, O.* (2024) Space Travel: The Radiation and Microgravity Effects on the Cardiovascular System. Int J Mol Sci. 25(21):11812. Space flight modulates the functions of the cardiovascular system. The exposure to space conditions can alter the cerebral blood flow, as well as the venous

Chera, A., Stancu-Cretu, M.*, Zabet, N.R. *, Bucur, O.* (2024) Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology. Epigenetics Chromatin. 17(1):39. DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense,

Fortner, A. and Bucur, O. (2024) Multiplexed spatial transcriptomics methods and the application of expansion microscopy. Front. Cell Dev. Biol. 12:1378875. While spatial transcriptomics has undeniably revolutionized our ability to study cellular organization, it has driven the development of a great number of innovative transcriptomics methods, which can be classified into in situ sequencing (ISS) methods, in situ hybridization

Georgescu, G.C., Cretu-Stancu, M. & Bucur, O. (2024) Metformin drugs under simulated gastric conditions can generate high nitrite-dependent levels of N-nitrosodimethylamine. Sci Rep 14, 13910. N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA), group 2A carcinogens, were detected in finished drug products, including metformin, ranitidine, sartans and other drugs which caused multiple recalls in the USA and Europe. Important