21/01/2025in publications Cocos, R. and Popescu, B.O. (2024) Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens. Hum Genomics. 18(1):141. Neurodegenerative diseases present complex genetic architectures, reflecting a continuum from monogenic to oligogenic and polygenic models. Recent advances in multi-omics data, c...
18/10/2024in publications Stilpeanu, R.I., Secara, B.S., Cretu-Stancu, M.*, Bucur, O.* (2024) Oncolytic Viruses as Reliable Adjuvants in CAR-T Cell Therapy for Solid Tumors. Int J Mol Sci. 25(20):11127. Although impactful scientific advancements have recently been made in cancer therapy, there remains an opportunity for future improvements. Immunotherapy is perhaps one of t...
01/10/2024in publications Mircea, A.A., Pistritu, D.V., Fortner, A., Tanca, A., Liehn, E.A. *, Bucur, O.* (2024) Space Travel: The Radiation and Microgravity Effects on the Cardiovascular System. Int J Mol Sci. 25(21):11812. Space flight modulates the functions of the cardiovascular system. The exposure to space conditions can alter the cerebral blood flow, as well as the v...
01/10/2024in publications Chera, A., Stancu-Cretu, M.*, Zabet, N.R. *, Bucur, O.* (2024) Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology. Epigenetics Chromatin. 17(1):39. DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome ina...
22/07/2024in publications Fortner, A. and Bucur, O. (2024) Multiplexed spatial transcriptomics methods and the application of expansion microscopy. Front. Cell Dev. Biol. 12:1378875. While spatial transcriptomics has undeniably revolutionized our ability to study cellular organization, it has driven the development of a great number of innovative transcriptomics methods, wh...
17/06/2024in publications Georgescu, G.C., Cretu-Stancu, M. & Bucur, O. (2024) Metformin drugs under simulated gastric conditions can generate high nitrite-dependent levels of N-nitrosodimethylamine. Sci Rep 14, 13910. N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA), group 2A carcinogens, were detected in finished drug products, including metformin,...
